Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part I: Neurophysiology.

نویسندگان

  • Florence Thibaut
  • Nash N Boutros
  • Marek Jarema
  • Bob Oranje
  • Alkomiet Hasan
  • Zafiris Jeffrey Daskalakis
  • Adam Wichniak
  • Andrea Schmitt
  • Peter Riederer
  • Peter Falkai
چکیده

The neurophysiological components that have been proposed as biomarkers or as endophenotypes for schizophrenia can be measured through electroencephalography (EEG) and magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), polysomnography (PSG), registration of event-related potentials (ERPs), assessment of smooth pursuit eye movements (SPEM) and antisaccade paradigms. Most of them demonstrate deficits in schizophrenia, show at least moderate stability over time and do not depend on clinical status, which means that they fulfil the criteria as valid endophenotypes for genetic studies. Deficits in cortical inhibition and plasticity measured using non-invasive brain stimulation techniques seem promising markers of outcome and prognosis. However the utility of these markers as biomarkers for predicting conversion to psychosis, response to treatments, or for tracking disease progression needs to be further studied.

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عنوان ژورنال:
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

دوره 16 5  شماره 

صفحات  -

تاریخ انتشار 2015